PHARMACOLOGY: PRACTICE 3

SINGLE BEST OPTION SERIES

         INSTRUCTION: SELECT THE SINGLE BEST OPTION

1.        The following are insulin secretagogues except:
   a.       Glipizide
   b.      Metformin
   c.       Chlorpropamide
   d.      Repaglinide
   e.      Nateglinide
   2.       The usual best treatment option for type 1 diabetes mellitus is:
   a.       Metformin
   b.      Glyburide
   c.       Insulin
   d.      Repaglinide
   e.      Pioglitazone
   3.       The most common toxic effects of metformin are on :
   a.       Cardiovascular
   b.      Renal
   c.       Gastrointestinal
   d.      Central nervous system
   e.      Haematologic
   4.       Which of the following is incorrect about using α-glucosidase inhibitors in the management of type 2 diabetes mellitus:
   a.       They delay the digestion and absorption of starch and disaccharides
   b.      Miglitol has effect on isomaltase and β-glucosidase
   c.       They lower post meal glycaemic excursions
   d.      Intervention with acarbose may also reduce cardiovascular diseases
   e.      Hypoglycaemia resulting from combining these drugs with sulphonylurea drugs is best treated with sucrose
   5.       The following antidiabetic drugs are injectables except:
   a.       Pramlintide
   b.      Exenatide
   c.       Levemir
   d.      Sitagliptin
   e.      None of the above
   6.       Which of the following is incorrect about insulin lispro?
   a.       It is produced by recombinant DNA technology
   b.      When injected subcutaneously, it is rapidly absorbed with onset of action within 5 to 15 minutes.
   c.       Its peak activity is as early as 1 hour after injection
   d.      It is dispensed as a turbid suspension at neutral P^H
   e.      None of the above
   7.       Treatment options for hypoglycaemia does not include:
   a.       Dextrose tablets or glucose gel
   b.      Sugar-containing beverages
   c.       Infusion of 50% glucose solution
   d.      Small amounts of honey in the buccal mucosa
   e.      Intramuscular injection of one gram of glucagon
   8.       Glipizide is contraindicated in diabetics with significant renal impairment to mainly prevent:
   a.       Arrhythmia
   b.      Hypoglycaemia
   c.       Hepatic failure
   d.      Uraemic encephalopathy
   e.      Renal stone formation
   9.       Annual screening of red blood cell parameters is encouraged in diabetics taking metformin because absorption of ..............................appears to be reduced during long term metformin therapy
   a.       Vitamin B2
   b.      Vitamin B12
   c.       Vitamin B6
   d.      Vitamin B1
   e.      Vitamin B3
   10.   Adverse effects of α-glucosidase inhibitors include the following except:
   a.       Flatulence
   b.      Constipation
   c.       Abdominal pains
   d.      Reversible hepatic enzyme elevation
   e.      None of the above
   
   
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