HISTOLOGY: PRACTICE 4

SINGLE BEST OPTION SERIES

         INSTRUCTION: SELECT THE SINGLE BEST OPTION

1.        Which of the following is incorrect about macrophages?
   a.       Epithelioid and multinucleated giant cells are found only in pathological conditions
   b.      They are antigen-presenting cells
   c.       They help in removing cell debris and damaged extracellular components
   d.      They do not have tumour-killing capacity
   e.      They participate in mediated resistance to infection
   2.       Which of the following is incorrect about ‘staining’ of tissues for histological examination?
   a.       Tissue components that stain more readily with basic dyes are termed basophilic
   b.      Acidic dyes stain the acidophilic components of tissues such as mitochondria, secretory granules and collagen
   c.       Hematoxylin is an acidic dye
   d.      Of all dyes, the combination of hematoxylin and eosin (H&E) is the most commonly used
   e.      Methods of staining tissues make various tissue components conspicuous and also permit distinctions to be made between them
   3.       Which of the following is incorrect about histochemistry and cytochemistry ?
   a.       The terms are used to indicate methods of localizing substances in tissue sections
   b.      DNA can be identified and quantified in cell nuclei using the Feulgen reaction
   c.       Histochemical methods usually permit identification of specific proteins in cells and tissues
   d.      They are used to diagnose storage diseases such as haemochromatosis, glycogenosis, mucopolysaccharidosis, and sphingolipidosis
   e.      None of the above
   4.       Which of the following is incorrect about tight junctions between epithelial cells?
   a.       Tight junctions are also called zonulae occludens
   b.      Their principal function is to form a seal that prevents the flow of materials between cells
   c.       They prevent paracellular pathway transport of materials
   d.      They are responsible for the syncytial contractions in the heart
   e.      None of the above
   5.       Which of the following is incorrect about glandular epithelia?
   a.       They are formed by cells specialized to produce secretions
   b.      Exocrine glands retain their connection with the surface epithelium from which they originate
   c.       Simple glands have only one branched duct
   d.      The small intestine and respiratory tract contain glandular epithelia in forms of goblet cells
   e.      None of the above
   6.       The ground substance of connective tissues contain the following except:
   a.       Glycosaminoglycans
   b.      Low density lipoproteins
   c.       Proteoglycans
   d.      Fibronectin
   e.      Laminin
   7.       Which of the following is incorrect about mast cells?
   a.       They are connective tissue cells
   b.      Their interior contain preformed granules such as heparin
   c.       Their principal function is the storage of chemical mediators
   d.      Their surface contain numerous receptors for immunoglobulin A (IgA)
   e.      They play a role in hypersensitivity reactions
   8.       The following are examples of acidic dyes used in histology except:
   a.       Orange G
   b.      Eosin
   c.       Fuchsin
   d.      Toluidine
   e.      None of the above
   9.       Concerning immunocytochemistry, which of the following is incorrect?
   a.       Labelled antibodies are used in identifying and localizing proteins and glycoproteins
   b.      One of the most important requirement is the availability of an antibody against the protein that is to be detected
   c.       Monoclonal antibodies are more important than polyclonal antibodies in detecting substances
   d.      Indirect method of immunocytochemistry is less sensitive than the direct method
   e.      None of the above
   10.   Which of the following is incorrect about junctions found between epithelial cells?
   a.       Zonula adherens encircles the cell and provides for the addition of one cell to its neighbours
   b.      Gap junctions are numerous in skeletal muscles
   c.       Gap junctions permit the exchange of materials between cells
   d.      Gap junctions enable cells in many tissues to act in a coordinated manner rather than independent units
   e.      The desmosome is a complex disc-shaped structure on the surface of one cell that is matched with identical structure of the adjacent cell
   
   
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